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Medical grade Hydroxyapatite coating powder with perfect spherical morphology which are used extensively in the orthopedic industry for implant coatings. Due to the influence of diseases, aging, frequent traffic accidents and other factors, bone injury cases increase year by year. According to statistics, there are 3 million orthopedic cases in China every year, so the demand for bone substitute materials is increasing. In recent years, Hydroxyapatite as a representative of bone substitute materials has gradually become a favorite in clinical application. Hydroxyapatite is the main component of vertebrate bones and teeth, which has good bioactivity and biocompatibility. Compared with the traditional metal (stainless steel, titanium alloy) and ceramic (alumina, silicon nitride) bone substitute materials, Hydroxyapatite not only has strong corrosion resistance and bone induction, but also eliminates the safety risks of the former by its degradation in vivo. At present, the research on Hydroxyapatite in bone substitute materials mainly focuses on two aspects: Hydroxyapatite coating and human bone biomimetic regeneration materials.